The Potential Benefits Of Adjuvant Therapy - 3460 Words

. In addition to patient perspectives on their treatment options and findings from a brief GA, a further consideration in estimating potential benefits of adjuvant therapy is the patient’s estimated life expectancy, to determine whether they are likely to live long enough to benefit from the treatment. Chronologic age is an integral component of such estimates; however, it is by no means a sufficient consideration. As our two clinical cases illustrate, two 70 year old breast cancer patients can have very different underlying health, physical activity, and social support systems and require a treatment approach that reflects these differences (Figure 1). It can be particularly challenging for physicians to estimate the life expectancy of their patients, especially for patients in advanced stages of cancer [35]. Fortunately, several tools are available to aid in the estimation of life expectancy in a variety of different patient populations (e.g. community dwelling or nursing ho me) and life expectancy time frame [36]. Many of these tools are available in an online calculator format on the â€Å"ePrognosis† website (www.eprognosis.com). For example the Lee- Schonberg index intakes into account the patient’s age, gender, body mass index, comorbidities, cigarette smoking, physical activity, previous hospitalizations, and limitations in activities of daily living due to physical, mental, emotional or cognitive problems to estimates the patient’s life expectancy [37-40]. None of theseShow MoreRelatedWhat Is Potential Therapeutic Targets?981 Words   |  4 PagesTherefore, a cancer that involves a mutation in these BRAC1 and BRAC2 genes (BRCAness) can be effectively treated with PARP1 inhibitors, which may represent very efficient therapies for TNBC because of the high sensitivity of these tumours to the inhibitor and moreimportantly, it is devoid of harmful effects on the remaining healthy cells. This contrasts with conventional chemothera pies, which are highly toxic to all cells and can provoke DNA damage in healthy cells that may further lead to secondaryRead MoreGenetic Testing Services Under Ms. Gelch Essay1143 Words   |  5 Pagesstates: â€Å"When claim number 201512106349125 (Genomic Health Inc.) was initially processed, it was denied as services that are experimental/investigational are not a covered benefit. The Oncotype DX colon cancer assay procedure is a genetic test. Ms. Gelch s policy specifically excludes coverage for genetic testing. There is no benefit available for genetic testing services under Ms. Gelch s policy.† There is a letter from Patrick Jensen at Genomic Health, Inc., dated 08/05/2016, that states: â€Å"Ms.Read MoreComplications Of Cancer And Treatments996 Words   |  4 Pages(breathlessness), and metastasis (cancer that spreads) (Mayo Clinic - Complications, 2016). Pain is one of the main physical complications, as the nerves surrounding the tissues feel the pressure due to growing tumor. Pain medications and alternate therapies like massage, yoga, and acupuncture can help patients to cope up with the pain (Mayo Clinic - Complications, 2016). Fatigue can be caused by the side effects of treatments as well and physical and mental distress. Fatigue can be managed through balancedRead MorePIK3C Case Study1100 Words   |  5 Pagesamplification. Other studies have explored whether HER2 gene amplification has a predictive role in predicting response to anti-EGFR therapy, but results have been contradictory. Some researchers have shown that HER2 gene amplification was positively correlated with resistance to cetuximab or pani ¬tumumab with poor PFS and a trend towards a worse OS (Barbara et al. 2012). Anti-HER2 therapy is used successfully in CRC preclinical trials and have demonstrated that combined EGFR and HER2 inhibition can initiateRead MoreAssessment Of Chronic Pain1329 Words   |  6 Pagesto achieve steady blood levels, and desired effects. To begin the treatment of chronic pain, weighing the cost of risks and benefits suggests that beginning with non-NSAIDS and working up to opioids is the best way to proceed. Research has suggested that acetaminophen should be the preferred treatment for older patients. (Reid, 2015) The only adverse side effect is potential hepatotoxicity. However, acetaminophen did not improve physical function or stiffness when tested with a placebo group. (ReidRead MoreA Brief Note On The Mammalian Target Of Rapamycin ( Mtor )1489 Words   |  6 Pagesversus combination tamoxifen and everolimus.[23] The combination treatment was associated with higher clinical benefit rate CBR (42% vs 61%; P =.045), and time to progression (TTP) (4.5 vs 8.6 months; hazard ratio [HR] =0.54; 95% confidence interval [CI], 0.36–0.81; P = .002). When patients were stratified based on primary hormone resistance, defined as relapse during adjuvant AI therapy or progression within 6 months of AI treatment in the metastatic setting, or secondary hormone resistance, definedRead MorePatients with Rheumatoid Arthritis and Emotion Regulation Therapy694 Words   |  3 PagesZautra et al. (2003) examined emotion regulation intervention against cognitive-behavioural therapy and a control condition. Patients with rheumatoid arthritis were provided with mindfullness and emotion regulation therapy (teaching skills to increase awareness, acceptance, and management of negative emotions, CBT for pain management, or health education (for control). Results showed that CBT outperformed mindfulness, but emotion regulation improved pain control, especially for patients with a historyRead MoreModern Medicine Must Not Be Possible Without The Discovery Of Antibiot ics1472 Words   |  6 Pagesor counterfeit medication being distributed and people would receive effective, more affordable treatments. Making antibiotics available after diagnosis and only by prescription, would help to decrease misuse and increase patient education about benefits and adverse effects of antibiotics (Laxminarayan et al., 2013). Even though some uses of antibiotics are highly regulated and carefully considered, they can still play a role in resistance. Prophylactic antibiotics make life saving proceduresRead MoreVaccine : Chromium Release Assay For Measure Cd4 +1476 Words   |  6 Pagesproliferation and ELISPOT to measure B cell responses. Tumour regression will be looked for using MRI techniques and visually on the skin. In all phases of clinical trials, patients that can no longer benefit from approved treatments will be used. Stage 3 and 4 patients only will be used due to potential side effects. Patients that do not respond to treatment after 6 months will be removed from the program. Patients that do respond will participate in the trials until death and will be monitored everyRead MoreLipase Inhibitor : Causes And Adverse Effects1576 Words   |  7 Pagesmg dose under prescription) and in Alli (Orlistat 60 mg dose over the counter). Dr Sidney Wolfe, Director of Public Citizen s Health Research Grou p, declared to the press that, These drugs have the potential to cause significant damage to multiple critical organs, yet they provide meager benefits in reducing weight loss in obese and overweight patients. According to this group, Orlistat should be banned because of increasing evidence that it causes liver damage, kidney stones and pancreatitis

Wendys - 7606 Words

Wendy Company Report to the Turnaround Committee Prepared By: ABC Consulting, LLC Bryant Perez August 12, 2013 TABLE OF CONTENTS Page Executive Summary Background Competition and the Market Field Reports and Competitive Analysis Problems Recommendations Summary Pro-Forman Income Statement Pro-Forma Balance Sheet Notes to Pro-Forma Statements Appendix A: Competitors amp; Ratios Appendix B: Field Reports Appendix C: Product Analysis Appendix D: Restructuring Timeline Executive Summary Wendy’s is currently the world’s 2nd largest quick-service hamburger company, operating 1,438 stores and franchising 5,177 store in the U.S. and 27†¦show more content†¦and 27 countries In 1970, Dave Thomas opened his second store which featured a state of the art drive-up window. In 1976 Wendy’s went public and opened its 500th store. In 1979, Wendy’s introduced the still popular â€Å"Where’s the Beef† advertising campaign. Following Dave Thomas’ vision, Wendy’s commits to ‘redefining quality’. Wendy’s states â€Å"our promise is to only use the freshest ingredients to create the best-tasting food for you. Quality is out promise and our recipe.† To that end, Wendy’s uses ‘fresh never frozen’ ingredients and make its food to order. In national taste tests, Wendy’s consistently outranks the competition in terms of quality and taste. Competition and the Market Wendy’s falls into the Quick Service Restaurant (QSR) industry. Their market is primarily driven by the demand from consumers for fast food products and services. This industry strives on high volume, low cost, and speedy service. In this industry it is not uncommon for food to be pre-prepared and re-heated for consumption. The result of this is customers are able to eat a familiar meal at each location, with standard menu’s and marketing across the entire market. Headquartered out of Columbus Ohio, The Wendy’s Company competes worldwide. With the majority of their operations in North America/Latin America, unlike their competitors Wendy’s has yet to venture in toShow MoreRelatedWendys International, Inc.1409 Words   |  6 PagesBurger King holding shares of approximately 2% each. Even though Wendy’s is number three in the hamburger chain, in 1990 Wendy’s was voted as having the best food in fast food burgers business, the best menu variet y and the most pleasant atmosphere. ANSWERS: Wendy’s is attempting to set themselves apart from their primary competitors of McDonald’s and Burger King by focusing on the following strategic advantages approaches: 1. Wendy’s website is user friendly and it shows that the company notRead MoreWendys Costing Methods4208 Words   |  17 PagesUVA-C-2206 WENDY’S CHILI: A COSTING CONUNDRUM What happens to a successful company when it loses its founder, senior chairman, advertising icon, and beloved leader? That was the question being asked about Wendy’s International, Inc., in January 2002 after Dave Thomas, 69, passed away from cancer. In the words of Jack Schuessler, the company’s chairman and CEO, â€Å"Dave was our patriarch. He was the heart and soul of our company.† Without him, the company would never be the same. However, Dave Read MoreManagerial Accounting -Wendys937 Words   |  4 PagesPam Powers MBA 516 Case Study: Wendy’s Chili: A costing Conundrum Dave Thomas was a man with a vision. He began his career in Columbus, Ohio in 1969 when he purchased a Kentucky Fried Chicken (KFC) franchise that was unprofitable. Dave turned that franchise into a profitable business and sold it back to KFC at a substantial profit. Dave had also co-founded Arthur Treacher’s Fish amp; Chips and was very familiar with the quick-service industry. However, hamburgers were Dave’s favoriteRead MoreCase Analysis: Profitability of Wendys Chilli.1657 Words   |  7 PagesDave Thomas, the founder of Wendys restaurant, opened his first restaurant on November 15, 1969 in Columbus, Ohio. Dave was born in Atlantic City, New Jersey on July 2, 1932. He was adopted at six weeks old by Rex and Auleva Thomas. Dave moved from state to state with his father when his mother passed at the age of 5. At the age of 12, Dave obtained his first job at a restaurant in Knoxville. Thus, he began his love for the restaurant business. At the age of 15, Dave drop ped out of high school toRead MoreWendys: Change Over Time Essay examples1780 Words   |  8 PagesHow and why has Wendy’s changed over time to become the restaurant it is today? Wendy’s is a quick serve, fast food burger chain, and is famous for their square patty, fresh, never frozen hamburgers. They are also well known for their catchy advertising and slogan’s. Wendy’s became the restaurant it is today through rapid expansion, the addition of new menu items, and incorporating creative advertising, all while never losing its identity of producing the freshest products with the freshest ingredientsRead MoreWendy s The Third Largest Fast Food Company1737 Words   |  7 PagesIntroduction Wendy’s is the third largest fast-food company in the United States. They are one of the most successful and profitable hamburger stores in the world. Through this, the industry is in a quagmire. One company is going to break through and develop a technique in which they will be able to limit the expenses and increase profit margin while adding stores. The company hat is able to develop this first will be able to control the fast-food industry. Wendy’s has the ability to do it by acknowledgingRead MoreFast Foods : Fast Food Restaurants834 Words   |  4 Pagesof the foods served? When one is choosing to eat at one of these restaurants, they may just simply choose one without evaluating things such as food quality, prices, and service experience. Two of these major food chains are Burger King and Wendy’s with Wendy’s placing third out of the most popular food chains in the world behind MacDonald’s and Burger King. When passing by one of these places, the first thing consumers notice is the huge sign in front of the restaurant whose main purpose is to attractRead MoreEssay about Organizational Structure- Mgt/2301127 Words   |  5 PagesMartha Miranda MGT/230 6/20/12 Kelley Parker Abstract The central thesis of this paper examines the organizational structures of McDonalds, Burger King, and Wendy’s food restaurants. It will examine the comparison and contrast of the organizational structure of McDonalds with Burger King, and Wendy’s Corporations. What functions influence McDonalds, and explains how the organizational design helps determine the structure that best suits McDonalds needs, as a business. OrganizationalRead MoreMcdonald’s Essay2988 Words   |  12 Pages There is much reluctance of competitors to imitate the successful efforts of another firm in their industry. And the only way to be successful by imitating is to beyond the original one. This idea can be proved by the example of McDonald’s and Wendy’s. McDonald’s Corporation is the world’s largest chain of hamburger fast food restaurants, serving around 68 million customers daily in 119 countries. 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The Vampire Diaries The Struggle Chapter Sixteen Free Essays

Long ago, in the dark side streets of Florence, starving, frightened, and exhausted, Stefan had made himself a vow. Several vows, in fact, about using the Powers he sensed within himself, and about how to treat the weak, blundering, but still-human creatures around him. Now he was going to break them all. We will write a custom essay sample on The Vampire Diaries: The Struggle Chapter Sixteen or any similar topic only for you Order Now As he’d thought, the surge of Power had passed over Bonnie and Meredith and followed him, but it had receded again, and was now drawn back, waiting. He wouldn’t let it wait long. Unencumbered by the burden of Elena’s body, he broke into a predator’s lope on the empty road. The freezing sleet and wind didn’t bother him much. His hunter’s senses pierced through them. He turned them all to the task of locating the prey he wanted. No thinking of Elena now. Later, when this was over. Tyler and his friends were still in the Quonset hut. Good. They never knew what was coming as the window burst into flying glass shards and the storm blew inside. Stefan meant to kill when he seized Tyler by the neck and sank his fangs in. That had been one of his rules, not to kill, and he wanted to break it. But another of the toughs came at him before he had quite drained Tyler of blood. The guy wasn’t trying to protect his fallen leader, only to escape. It was his bad luck that his route took him across Stefan’s path. Stefan flipped him to the ground and tapped the new vein eagerly. The hot coppery taste revived him, warmed him, flowed through him like fire. It made him want more. Power. Life. They had it; he needed it. With the glorious rush of strength that came with what he’d already drunk, he stunned them easily. Then he moved from one to another, drinking deep and throwing them away. It was like popping tops on a six-pack. He was on the last when he saw Caroline huddling in the corner. His mouth was dripping as he raised his head to look at her. Those green eyes, usually so narrow, showed white all around like those of a terrified horse. Her lips were pale blurs as she gabbled soundless pleas. He pulled her to her feet by the green sashes at her waist. She was moaning, her eyes rolling up in their sockets. He wound his hand in her auburn hair to position the exposed throat where he wanted it. His head reared back to strike – and Caroline screamed and went limp. He dropped her. He’d had enough anyway. He was bursting with blood, like an overfed tick. He had never felt so strong, so charged with elemental power. Now it was time for Damon. He went out of the Quonset hut the same way he’d come in. But not in human form. A hunting falcon soared out the window and wheeled into the sky. The new shape was wonderful. Strong†¦ and cruel. And its eyes were sharp. It took him where he wanted, skimming over the oak trees of the woods. He was looking for a particular clearing. Stefan ripped bloody strips out of his arms and heard Damon’s answering scream of pain and anger. I’m not your weak little brother any more. He sent the thought down to Damon on a stunning blast of Power.And this time I’ve come for your blood. He felt the backwash of hatred from Damon, but the voice in his mind was mocking.So this is the thanks I get for saving you and your betrothed ? Stefan’s wings folded and he dived again, his whole world narrowed to one objective. Killing. He went for Damon’s eyes, and the stick Damon had picked up whistled past his new body. His talons tore into Damon’s cheek and Damon’s blood ran. Good. You shouldn’t have left me alive, he told Damon.You should have killed both of us at once. I’ll be glad to correct the mistake! Damon had been unprepared before, but now Stefan could feel his drawing Power, arming himself, standing ready.But first you might tell me whom I’m supposed to have killed this time. The falcon’s brain could not deal with the riot of emotions the taunting question called up. Screaming wordlessly, it plummeted on Damon again, but this time the heavy stick struck home. Injured, one wing hanging, the falcon dropped behind Damon’s back. Stefan changed to his own form at once, scarcely feeling the pain of his broken arm. Before Damon could turn, he grabbed him, the fingers of his good hand digging into his brother’s neck and spinning him around. When he spoke, it was almost gently. â€Å"Elena,† he said, whispered, and went for Damon’s throat. It was dark, and very cold, and someone was hurt. Someone needed help. But she was terribly tired. Elena’s eyelids fluttered and opened and that took care of the darkness. As for the cold†¦ she was bone-cold, freezing, chilled to the marrow. And no wonder; there was ice all over her. Somewhere, deep down, she knew it was more than that. What had happened? She’d been at home, asleep – no, this was Founders’ Day. She’d been in the cafeteria, on the stage. Someone’s face had looked funny. It was too much to cope with; she couldn’t think. Disembodied faces floated before her eyes, fragments And so tired. Better go back to sleep then. The ice wasn’t really that bad. She started to lie down, and then the cries came to her again. She heard them, not with her ears, but with her mind. Cries of anger and of pain. Someone was very unhappy. She sat quite still, trying to sort it all out. There was a quiver of movement at the edge of her vision. A squirrel. She could smell it, which was strange because she’d never smelled a squirrel before. It stared at her with one bright black eye and then it scampered up the willow tree. Elena realized she’d made a grab for it only when she came up empty with her fingernails digging into bark. Now that was ridiculous. What onearth did she want a squirrel for? She puzzled over it for a minute, then lay back down, exhausted. The cries were still going on. She tried to cover her ears, but that did nothing to block them out. Someone was hurt, and unhappy, and fighting. That was it. There was a fight going on. All right. She’d figured it out. Now she could sleep. She couldn’t, though. The cries beckoned to her, drew her toward them. She felt an irresistible need to follow them to their source. Andthen she could go to sleep. After she saw†¦ him. Oh, yes, it was coming back now. She rememberedhim. He was the one who understood her, who loved her. He was the one she wanted to be with forever. His face appeared out of the mists in her mind. She considered it lovingly. All right, then. Forhim she would get up and walk through this ridiculous sleet until she found the proper clearing. Until she could join him. Then they’d be together. The very thought of him seemed to warm her. There was a fire inside him that few people could see. She saw it, though. It was like the fire inside her. He seemed to be having some sort of trouble at the moment. At least, there was a lot of shouting. She was close enough to hear it with her ears as well as her mind now. There, beyond that grandfather oak tree. That was where the noise was coming from. He was there, with his black, fathomless eyes, and his secret smile. And he needed her help. She would help him. Shaking ice crystals out of her hair, Elena stepped into the clearing in the wood. How to cite The Vampire Diaries: The Struggle Chapter Sixteen, Essay examples